Purpose: Exosomes (EXOs) mediate local and systemic cell-tocell communication and regulate cell behavior by transferring mRNA, miRNAs and proteins to recipient cells. Recently, we demonstrated that bone marrow (BM) cancer associated fibroblasts (CAFs) promote tumor progression and drug resistance (DR) in multiple myeloma (MM) (1-3). In this study, we analysed the effect of MM-derived EXOs on CAFs in MGUS to MM transition and, in turn, the effect of CAFs-derived EXOs on endothelial (ECs) and MM cells. Methods: EXOs isolation was performed from conditioned medium (CM) of CAFs purified from BM aspirates of 8 active MM patients and from CM of cultured RPMI8226 and U266 MM cells. Electron microscopy (TEM), dual immunofluorescence-con...
The role of cancer-associated fibroblasts (CAFs) has not been previously studied in multiple myeloma...
Angiogenesis and immunosuppression promote multiple myeloma (MM) development, and osteolysis is a pr...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They m...
Purpose: Exosomes (EXOs) mediate local and systemic cell-tocell communication and regulate cell beh...
: Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between MM cells and...
Multiple myeloma (MM) is a hematological disease that is still not curable. The bone marrow milieu, ...
Exosomes are small membrane vesicles (30\u2013100 nm) derived from the luminal membranes of multives...
Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between MM cells and b...
BACKGROUND-AIM Multiple Myeloma (MM) is characterized by clonal proliferation of PCs in the bone mar...
Multiple myeloma (MM) pathogenesis and progression largely rely on the cells and extracellular facto...
Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful...
The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a c...
Although major advances have been achieved in the treatment of chronic myeloid leukemia (CML) by usi...
Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between tumor cells...
PURPOSE: microRNAs (miRs) regulate gene expression at post-transcriptional level modulating several ...
The role of cancer-associated fibroblasts (CAFs) has not been previously studied in multiple myeloma...
Angiogenesis and immunosuppression promote multiple myeloma (MM) development, and osteolysis is a pr...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They m...
Purpose: Exosomes (EXOs) mediate local and systemic cell-tocell communication and regulate cell beh...
: Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between MM cells and...
Multiple myeloma (MM) is a hematological disease that is still not curable. The bone marrow milieu, ...
Exosomes are small membrane vesicles (30\u2013100 nm) derived from the luminal membranes of multives...
Multiple myeloma (MM) progression and drug resistance depend on the crosstalk between MM cells and b...
BACKGROUND-AIM Multiple Myeloma (MM) is characterized by clonal proliferation of PCs in the bone mar...
Multiple myeloma (MM) pathogenesis and progression largely rely on the cells and extracellular facto...
Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful...
The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a c...
Although major advances have been achieved in the treatment of chronic myeloid leukemia (CML) by usi...
Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between tumor cells...
PURPOSE: microRNAs (miRs) regulate gene expression at post-transcriptional level modulating several ...
The role of cancer-associated fibroblasts (CAFs) has not been previously studied in multiple myeloma...
Angiogenesis and immunosuppression promote multiple myeloma (MM) development, and osteolysis is a pr...
Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They m...